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相关概念视频

Rh Blood Group01:19

Rh Blood Group

1.8K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.8K
Blood Types02:20

Blood Types

18.3K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
18.3K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

11.2K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

Blood Transfusion

810
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
810
Blood Typing01:10

Blood Typing

1.5K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.5K
Multiple Allele Traits01:49

Multiple Allele Traits

34.9K
The Concept of Multiple Allelism
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相关实验视频

Updated: Sep 12, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

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红细胞与免疫接种免疫遗传风险因素

Pascal Pedini1, Jacques Chiaroni1, Christophe Picard1

  • 1Immunohematology and Immunogenetics Laboratory, French Blood Establishment, Marseille, France; Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France.

Current opinion in immunology
|August 6, 2025
PubMed
概括

了解为什么一些患者在输血红细胞 (RBC) 后产生alloantibodies是关键. 人类白细胞抗原 (HLA) 和微化学反应等遗传因素影响这种免疫反应,指导未来的输血策略.

科学领域:

  • 免疫学 免疫学 免疫学
  • 输血医学 输血医学
  • 遗传学 遗传学 是一个

背景情况:

  • 当接受者的免疫系统在输血红细胞 (RBCs) 上产生对外抗原的抗体时,会发生合免疫.
  • 在红细胞输血后的alloantibody发育中存在个体变异性,这表明了潜在的调节因素.
  • 人体白细胞抗原 (HLA) 系统,包括古典和非古典分子,在调节免疫反应方面发挥作用,特别是在状细胞疾病等疾病中.

研究的目的:

  • 探索导致红细胞输血后与免疫接种的个体差异的因素.
  • 研究人类白细胞抗原 (HLA) 多态性和自然胎儿母体微化学性在调节免疫反应中的作用.
  • 突出需要先进的遗传策略,以改善捐赠者-接受者匹配和减少免疫接种.

主要方法:

  • 审查现有证据,关于HLA系统和微化学的作用在Alloimmunization.
  • 讨论红细胞抗原和HLA跨种族群体的遗传多样性的影响.
  • 强调高通量测序技术的实用性,以加强捐赠者与接受者匹配.

主要成果:

  • 越来越多的证据表明,古典和非古典的HLA系统在调节对外来红细胞抗原的幽默性免疫反应方面存在影响.
  • 自然的胎儿-母亲微化学反应被确定为影响非免疫反应个体变异性的潜在因素.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

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Last Updated: Sep 12, 2025

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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  • 红细胞抗原和HLA的遗传多样性需要针对个性化输血医学进行先进的基因定型.

    • 结论:

    • 遗传因素,包括HLA和微化学性,显著影响艾洛免疫的风险.
    • 高通量测序和基因型策略对于评估个体抗体发育风险至关重要.
    • 未来的策略应侧重于指导选择兼容的RBC单元,以尽量减少免疫接种.