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在没有糖尿病视网膜病变的糖尿病患者中,通过OCT血管学评估视神经头部的微血管变化

A Zahaf¹, I Jlassi¹, H Lajmi¹

¹Department of Ophthalmology, Internal Security Forces Hospital, La Marsa, Tunis, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Journal francais d'ophtalmologie

|August 6, 2025

概括

光学连贯断层扫描血管造影 (OCTA) 显示,在没有糖尿病视网膜病变 (DR) 的糖尿病患者中,视神经头血管密度降低. 这突出了糖尿病早期的微血管变化,甚至在DR发病之前.

科学领域:

眼科医生眼科眼科
糖尿病学糖尿病学
医疗成像医学成像

背景情况:

糖尿病视网膜病变 (DR) 是全球失明的主要原因.
光学连贯断层扫描血管造影 (OCTA) 可视化视网膜和视神经头部的微血管.
在糖尿病中早期发现微血管变化至关重要.

研究的目的:

用OCT-A在没有DR的糖尿病患者和健康对照中比较光盘和周周血管密度.
调查微血管变化与糖尿病相关风险因素之间的相关性.
评估视神经头部早期的微血管变化.

主要方法:

对60名糖尿病患者 (没有DR) 的102只眼睛和40名健康对照组 (年龄在45-65岁之间) 的74只眼睛进行横截面研究.
进行了眼科检查,OCT和OCT-A.
视觉盘/周周细胞微血管密度和RNFL厚度的量化;使用相关性和回归的统计分析.

主要成果:

与对照组相比,没有DR的糖尿病患者的整体乳头血管密度 (WPVD) 和周围乳头血管密度 (PPVD) 显著降低 (P<0.001和P=0.003,分别).
两组之间没有发现视网膜神经纤维层 (RNFL) 厚度的显著差异 (P=0.132).
RNFL厚度与年龄和HbA1c负相关 (P=0.047,P=0.039),但PPVD与年龄,糖尿病持续时间,HbA1c或脂质失调没有相关.

结论:

在DR发病之前,OCT-A检测到糖尿病患者视神经头部血管密度下降的情况.
这表明糖尿病的早期微血管变化.
需要进一步的研究来确定OCT-A在早期DR检测和监测中的作用.

关键词:

糖尿病视网膜病变 - 糖尿病视网膜病变这是一个光盘光学.视神经的头部视神经的头部光学连贯性断层扫描血管图谱.视网膜神经纤维层厚度视网膜神经纤维层厚度糖尿病视网膜病变糖尿病视网膜病变断层扫描通过光学连贯性血管图谱.视网膜神经纤维的厚度

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