长期悲伤障碍中大脑网络连接的破坏:与悲伤相关的回避,渴望和侵入性思想的关系
Nutta-On P Blair1, Gyujoon Hwang1, B Douglas Ward1
1Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
概括
突出 (SN) 和默认模式 (DMN) 网络之间的异常连接与长期悲伤障碍 (PGD) 症状有关. 在PGD中,更广泛的脑网络干扰与侵入性思想,渴望和回避有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 大规模的大脑网络功能障碍与神经精神疾病有关.
- 网络互动中断可能是长期悲伤障碍 (PGD) 症状的基础.
研究的目的:
- 调查PGD患者和悲伤综合症患者的大脑网络之间的休息状态功能连接 (rsFC) 差异.
- 探索大脑网络连接和PGD症状严重程度之间的关系.
主要方法:
- 一项横截面功能磁共振成像 (fMRI) 研究比较了可能患有PGD (n=42) 和综合悲伤 (n=45) 的老年人的rsFC.
- 分析了八个大型网络,并计算了对之间的rsFC强度.
- 低频波动的分数幅度 (fALFF) 评估了网络内部的差异,并探索了与临床症状的关系.
主要成果:
- 与对照组相比,患有PGD的人在突出网络 (SN) 和默认模式网络 (DMN) 之间显示出更高的rsFC (p<0.05修正).
- 这种SN-DMN连接与悲伤的严重程度和避免有积极的相关性.
- 在PGD中,更广泛的网络之间的连接中断与侵入性思想,渴望和回避症状有关.
结论:
- 异常的SN-DMN连接是PGD悲伤严重程度和避免的神经生物学相关.
- 广泛的脑网络连接中断与核心PGD症状有关,这表明网络功能障碍在疾病的病理生理学中发挥了作用.
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