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臭氧对脏移植结果的影响
Seung Hyun Han1, Eunjin You2, Ara Ko3
1Division of Nephrology, Department of Internal Medicine-Nephrology, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
概括
长期暴露于臭氧 (O3) 显著增加了移植接受者的移植失败和死亡风险. 这项研究强调了臭氧.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 移植科学 移植科学
背景情况:
- 空气污染对脏疾病的结果产生不利影响.
- 臭氧 (O3) 对移植 (KT) 接受者的特定影响尚不清楚.
研究的目的:
- 研究长期暴露于臭氧 (O3) 对移植 (KT) 结果的影响.
- 评估O3暴露与KT接受者的不良事件之间的关联.
主要方法:
- 这是一项多中心的纵向队列研究,对4796名韩国成年KT接受者进行了研究 (2002-2020年).
- 使用高分辨率机器学习模型估计的臭氧 (O3) 和细颗粒物 (PM2.5) 暴露量.
- 时间变化的考克斯比例危险模型用于评估与所有原因死亡率和死亡审查的移植缺陷的关联,调整为PM2.5.5.
主要成果:
- 氧3度增加5ppb与死亡审查的移植失败风险增加1.60倍有关.
- 氧3度增加5ppb与所有死因死亡风险增加1.65倍有关.
- 关联在子组和敏感性分析中保持一致.
结论:
- 长期暴露于臭氧 (O3) 与死亡审查的移植失败和移植受体全因死亡风险显著增加有关.
- 这些发现扩大了对空气污染对健康的影响的理解,特别是对脆弱的KT人群.
- 强调需要制定策略,以减轻 KT 接受者的 O3 暴露.
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