相关实验视频

Updated: Sep 12, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

在加泰罗尼亚实施nirsevimab免疫预防后,HRSV的进化动态 (2023-2024)

Alejandra González-Sánchez¹, Cristina Andrés², Ignasi Prats-Méndez²

¹Respiratory Viruses Unit, Virology Section, Microbiology Department, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Genetics and Microbiology, School of Biosciences, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

The Journal of infection

|August 6, 2025

概括

尼尔塞维玛单克隆抗体可能会改变人类呼吸道同胞病毒 (HRSV) 的演变,特别是HRSV-B. 持续的基因组监测对于早期检测潜在的耐尼塞维马布基因突变来说至关重要.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

人类呼吸道同胞病毒 (HRSV) 是呼吸道疾病的主要原因之一.
尼尔塞维马布是一种单克隆抗体 (mAb),用于预防HRSV.
了解nirsevimab对HRSV演变的影响对于公共卫生至关重要.

研究的目的:

评估Nirsevimab在加泰罗尼亚2023-2024赛季对HRSV的选择性压力.
为了分析病毒突变,多样性和进化动态在nirsevimab免疫和非免疫个体.
为了确定与nirsevimab暴露相关的HRSV的潜在遗传变化.

主要方法:

从加泰罗尼亚的哨兵网络和医院收集呼吸道样本.
全基因组测序 (WGS) 或HRSV阳性样本的F基因测序.
遗传学分析,多样性评估和选择压力分析.

主要成果:

从251个非免疫和79个免疫病例中获得的数据进行测序.
群体之间的血统分布相似;在免疫HRSV-B中观察到减少的核酸多样性.
在免疫样本中转向中性进化;在nirsevimab表位组中检测出突变,包括K209E (HRSV-A) 和K68E (HRSV-B),在非免疫样本中缺席.

结论:

尼尔塞维马布免疫可能会影响HRSV的进化途径,特别是对于HRSV-B.
在免疫个体中,在nirsevimab表位内发现了特定的突变.
建议进行持续的基因组监测,以尽早检测抗mAb的HRSV突变体.

关键词:

基因漂移是因为基因漂移.基因适应性基因适应性人类呼吸道突触性病毒分子进化分子进化一个单克隆抗体的抗体.人口遗传学人口遗传学公共卫生监督公共卫生监督整个基因组测序测序整个基因组测序

更多相关视频

Cost-effective Method for Microbial Source Tracking Using Specific Human and Animal Viruses

Cost-effective Method for Microbial Source Tracking Using Specific Human and Animal Viruses

Published on: December 3, 2011

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

相关概念视频

Viral Mutations

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...