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Updated: Sep 12, 2025

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
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Published on: October 9, 2016

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该SeqSplice多重小基因拼接试验用于表征和定量变异诱导的BRCA1和BRCA2拼接异型

Daffodil M Canson1, Michael T Parsons1, Gemma Moir-Meyer2,3

  • 1Population Health Program, QIMR Berghofer, Herston, Queensland 4006, Australia.

Genome research
|August 6, 2025
PubMed
概括

SeqSplice是一种新的RNA拼接方法,可以准确地分类影响遗传癌症风险的罕见BRCA1/BRCA2变异. 该工具通过量化结合改变变异效应,特别是影响新结合部位的变异效应,来帮助临床决策.

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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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