制造业压力不会对患有糖尿病的捐赠者的红细胞产生差异性影响
Celina Phan1,2, Elyn M Rowe3, Mahsa Yazdanbakhsh1,2
1Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
Vox sanguinis
|August 6, 2025
概括
在患有糖尿病的捐献者中,血液处理不会恶化红细胞 (RBC) 质量. 2型糖尿病捐赠者在后处理过程中显示了红细胞指数和氧 afinity 的持续差异,突出显示了捐赠者的健康影响.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 糖尿病研究 糖尿病研究
背景情况:
- 糖尿病患病率的增加和捐赠者标准的扩大导致更多的糖尿病人献血.
- 对常规血液制造如何影响来自糖尿病捐献者的红细胞 (RBC) 的理解有限.
研究的目的:
- 在加工成红细胞缩物 (RCC) 后,检查来自1型糖尿病 (T1D) 或2型糖尿病 (T2D) 的捐赠者红细胞的差异.
主要方法:
- 从T1D,T2D和非糖尿病供体收集全血 (WB).
- 使用过方法将WB加工成RCC.
- 在采集后的第二天特征WB和RCCs.
主要成果:
- 糖尿病捐赠者具有更高的糖化血红蛋白 (HbA1c) 水平.
- 处理在所有组中增加了红细胞计数,血红蛋白和血红素.
- 与对照组相比,患有T2D的捐赠者表现出平均体质血红蛋白 (MCH),平均体质血红蛋白度 (MCHC) 和p50的降低,在后期处理中持续存在.
结论:
- 血液成分制造不会加剧患有糖尿病的献血者对红细胞的压力.
- 患有T2D的捐赠者在MCH,MCHC和p50.0中存在持久的变化.
- 献血者的健康显著影响血液产品的质量.
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