在ARCADIA-MRI中MRI发现内出血:ARCADIA试验的辅助研究
Hui Chen1, Maarten Lansberg1, Guangming Zhu1
1From the Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Stanford Stroke Center, Palo Alto, CA, USA; Department of Neurology, The University of Arizona, Tucson, AZ, USA; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle, USA; Center for Brain & Mind Health, Yale School of Medicine, New Haven, Connecticut, USA; Department of Neurology, Weill Cornell Medicine, New York, NY, USA; Department of Neurology, School of Medicine and Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; and American Heart Association, Dallas, TX, USA.
艾皮克萨班和阿司匹林在密码性中风后的患者中显示出类似的事件出血事件,包括脑内出血和微型出血. 这项探索性分析发现,在两种抗血栓治疗之间,MRI检测到的出血病变没有显著差异.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 心脏病学 心脏病学
背景情况:
- 作为ARCADIA试验的辅助分析,ARCADIA-MRI研究调查了用于二次中风预防的抗血栓治疗方法.
- 之前的发现表明,与阿司匹林相比,阿皮克萨班的非性隐性心脏病发作风险较低.
研究的目的:
- 探索阿皮克萨班与阿司匹林对MRI检测到的出血病变的影响.
- 为了比较治疗组之间的脑内出血,微型出血和表面 siderosis 的发生率.
主要方法:
- 来自ARCADIA-MRI参与者的MRI扫描 (阿皮克萨班与阿司匹林) 被盲目的评定者评估.
- 放射性终点包括发生的脑内出血 (>10毫米),微型出血 (≤10毫米) 和表面 siderosis.
- 随访持续时间从4个月到5.3年 (中位数为27个月).
主要成果:
- 在阿皮克萨班和阿司匹林组之间,脑内出血 (5.1%对6.4%),微型出血 (7.8%对10.8%) 或表面 siderosis (7.7%对12.9%) 的发生率没有显著差异.
- 基线MRI发现在两种治疗手臂中都是相似的.
- 所有出血事件的p值都大于0.05,表明没有统计学上显著的差异.
结论:
- 对ARCADIA-MRI子研究的探索性分析显示,在接受阿皮克萨班和阿司匹林治疗的患者中,发生事件出血的MRI发现类似.
- 这些结果表明,在这个患者群体中,阿皮克萨班和阿司匹林之间的出血病变的安全性是可比的.
相关概念视频
Imaging Studies for Cardiovascular System IV: CMRI
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Hemorrhagic Stroke l: Introduction


