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Updated: Sep 12, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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Cas13跨核酶活动的RNA目标独立非正规激活 (RINCA)

Wenjun Liu1, Xuena Zhu2, Yuanyuan Xue2

  • 1Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China; The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Zhejiang University Cancer Center, Hangzhou 310003, China; MOE Joint International Research Laboratory of Pancreatic Diseases, Hangzhou 310003, China.

Science bulletin
|August 6, 2025
PubMed
概括

我们在Cas13中发现了RNA目标独立的非正规激活 (RINCA),使CRISPR的新应用成为可能. 优化的Cas13变种降低了毒性,改善了生物传感,而RINCA系统则提供了治疗潜力.

关键词:
克里斯普尔-Cas13是什么意思在生物体内安全性肝癌是一种肝癌.非正典的非正典的跨核酶活动活动.

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