抗生素对肠道微生物群的影响跨越不同的地理区域
Luna Eresta Jaya1, Ilana L Brito1
1Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Trends in microbiology
|August 6, 2025
概括
抗生素的使用会改变肠道微生物群,而地理位置的变化会影响健康. 需要在低收入和中等收入国家 (LMICs) 进行更多的研究,以了解抗生素耐药性基因库和长期健康影响.
科学领域:
- 微生物组研究的研究.
- 全球卫生健康 全球卫生健康
- 抗生素耐药性 抗生素耐药性
背景情况:
- 抗生素的使用显著影响肠道微生物群和健康结果.
- 微生物组合的地理变化,抗生素耐药性基因 (ARG),抗生素使用和饮食影响治疗反应.
- 目前的微生物组研究严重偏向北美和欧洲人口,限制了全球的理解.
研究的目的:
- 强调需要扩大对低收入和中等收入国家 (LMICs) 抗生素影响的研究.
- 强调LMIC肠道微生物组作为抗生素耐药性基因 (ARG) 的储库的作用.
- 强调研究抗生素对慢性病的长期影响以及疫苗在不同人群中的疗效的重要性.
主要方法:
- 关于肠道微生物组组成和抗生素耐药性的现有文献的审查.
- 分析微生物组研究和抗生素使用模式的地理差异.
- 识别代表性不足的地区对抗生素效应的知识差距.
主要成果:
- 大多数微生物组数据来源于西方国家,在全球范围内了解抗生素影响方面存在差距.
- 越来越多的抗生素在LMICs使用需要监测ARGs的肠道微生物组.
- 抗生素对慢性疾病和疫苗疗效的长期影响尚不清楚,特别是在不同的人群中.
结论:
- 需要进行涉及不同种群和抗生素类别的机制研究.
- 了解地理差异对于全球微生物群的弹性和改善健康结果至关重要.
- 对LMIC的监测和研究对于管理抗生素耐药性和公共卫生至关重要.
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