HDL胆固醇作为母乳养和冠状动脉样硬化之间的关系的调解者从双步门德尔随机化分析的两个步骤
Baoquan Zhang1, Bin Yang2, Wenlong Xiu2
1Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, China. zbq2701@fjmu.edu.cn.
Scientific reports
|August 6, 2025
概括
哺乳与降低冠状动脉样硬化 (CA) 的风险有关. 这种保护作用可能部分由增加的高密度脂蛋白胆固醇 (HDL-C) 水平介导.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 哺乳与冠状动脉样硬化 (CA) 之间的关系仍在争论中.
- 研究早期生活因素,如母乳养,对于理解心血管疾病 (CVD) 病因至关重要.
- 门德尔随机化 (MR) 提供了一种可靠的方法来探索暴露和结果之间的因果关系.
研究的目的:
- 使用孟德尔随机化 (MR) 调查母乳养和冠状动脉样硬化 (CA) 之间的因果关系.
- 确定潜在的调解因素,如脂质概况,以解释母乳养和CA之间的联系.
- 评估高密度脂蛋白胆固醇 (HDL-C) 作为这种关联中介者的作用.
主要方法:
- 利用两个独立的欧洲成年人队伍进行发现和复制分析.
- 针对CA和母乳养表型,使用了来自大型全基因组关联研究 (GWAS) 的总结统计数据.
- 进行了两步MR分析,以评估候选变量的调解效应,包括HDL-C.
主要成果:
- 在发现 (OR:0.826) 和复制 (OR:0.439) 数据集中,MR分析显示,母乳养与降低CA风险之间存在显著的保护性关联.
- 高密度脂蛋白胆固醇 (HDL-C) 被确定为一个重要的调解者,解释了总效应的10.26%.
- 这些发现表明,母乳养对CA具有保护作用,部分是通过提高HDL-C水平.
结论:
- 哺乳表明对冠状动脉样硬化有因果保护作用.
- 增加的HDL-C水平代表了母乳养对心脏保护益处的关键调解途径.
- 促进母乳养可能是对长期心血管健康的有价值的早期干预策略.
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