抑郁症调解了脂质积累产物和过度活跃的膀之间的关联
Caijuan Huang1, Ying Xu1, Yibing Guan2
1Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Scientific reports
|August 6, 2025
概括
较高的脂质积累产品 (LAP) 水平与过度活性膀 (OAB) 的风险增加有关. 抑郁症部分调解了这种关联,突出了干预的潜在途径.
科学领域:
- 代谢健康和泌尿病学
- 公共卫生和流行病学.
- 心理健康及其生理相关的心理健康.
背景情况:
- 脂质积累产物 (LAP) 和过度活跃的膀 (OAB) 之间的关系仍然未被探索.
- 了解OAB的潜在风险因素和调解途径对于公共卫生至关重要.
研究的目的:
- 调查LAP和OAB之间的关联.
- 检查抑郁症在LAP-OAB关系中的调解作用.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 的七个周期 (2005-2018) 的数据.
- 采用多变量逻辑回归,受限立方线 (RCS),子组分析和随机森林 (RF) 进行分析.
- 使用已确定的分析方法,研究了抑郁症的调解作用.
主要成果:
- 在LAP和OAB之间发现了显著的线性正相关性 (AOR: 1.158,P < 0.001).
- 在LAP的最高四分位数中,与最低四分位数相比,OAB患病率显著增加 (AOR: 1.320,P = 0.002).
- 女性性别被确定为一个显著的相互作用变量,LAP是与OAB相关的关键因素.
- 抑郁症约占LAP和OAB之间的关联的10%.
结论:
- 在LAP和OAB之间存在线性正相关性,性别有显著的相互作用效应.
- 抑郁症在LAP和OAB之间的关系中扮演着重要的中间因素.
- 这些发现表明OAB预防和管理策略的潜在目标,考虑代谢因素和心理健康.
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