在有或没有吸入性皮质类固醇治疗的儿科喘患者中评估后部段变化
Ulviye Kıvrak1,2, Fatih Çiçek3, Mehmet Tolga Köle4
1Department of Ophthalmology, Kartal Dr Lütfi Kırdar City Hospital University of Health Sciences, Cevizli, D-100 Güney Yanyol, Cevizli Mevkii No:47, 34865, Kartal, Istanbul, Turkey. dr.ulviyekivrak@hotmail.com.
Scientific reports
|August 6, 2025
概括
儿童喘患者表现出后部细分血管性和胸腔厚度降低,可能与炎症和缺氧有关. 通过光学连贯断层扫描 (OCT) 和OCT血管造影 (OCTA) 的早期检测有助于维护视力.
科学领域:
- 眼科医生 眼科 眼科
- 儿科肺病学 儿科肺病学
- 医疗成像医学成像
背景情况:
- 喘是一种影响儿童的慢性炎症性疾病,具有潜在的全身影响.
- 吸入性皮质类固醇是儿童喘的常见治疗方法.
- 眼睛的后部部分,包括视网膜血管和胆,可能会受到系统性炎症和缺氧的影响.
研究的目的:
- 评估和比较儿童喘患者的后部部位变化.
- 调查喘,吸入性皮质类固醇使用和眼部微血管之间潜在的关联.
- 评估光学连贯断层扫描 (OCT) 和OCT血管学 (OCTA) 在儿科喘研究中的实用性.
主要方法:
- 对患有亚图皮性喘的儿科患者 (7-17岁) 的回顾性分析.
- 分类为组:没有吸入性皮质类固醇,吸入性皮质类固醇治疗和健康对照.
- 收集人口统计,临床和实验室数据 (生细胞计数,IgE,CRP).
- 使用OCT和OCTA评估后部部分参数.
主要成果:
- 与对照人群相比,喘患者表现出明显减少的亚叶胆道厚度.
- 在喘患者中观察到表面毛细管和胆毛细管密度的减少.
- 在喘患者的下方和上方象限中,周周血管密度明显较低.
- 炎症标志物 (乙氨基细胞计数,CRP) 与血管密度变化相关.
结论:
- 喘,作为一种炎症和缺氧状况,显著影响儿童的后部段参数.
- 在儿科喘患者中可能会发生视网膜和状腺的微血管变化.
- OCT和OCTA是检测早期微血管变化的宝贵工具,并为视觉健康干预提供信息.
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