在跨性别大鼠模型中,性别肯定性雌激素治疗的心血管风险
D S Escudero1,2, V R Martínez1,3, Y Pirosanto1,4
1Centro de Investigaciones Cardiovasculares Dr. Horacio E. Cingolani, Universidad Nacional de La Plata, Facultad de Ciencias Médicas de La Plata, Calle 60 y 120La Plata, 1900, Buenos Aires, Argentina.
概括
在患有高血压的跨性别雌性 (TGF) 鼠群中,雌激素治疗 (ET) 显示出复杂的心血管效应. 虽然ET改善了氧化压力等某些方面,但它恶化了脂质管理和心脏收缩性,表明性别肯定激素治疗 (GAHT) 的潜在心血管风险.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 动物模型 动物模型
背景情况:
- 有限的临床证据证实了与性别肯定激素治疗 (GAHT) 相关的心血管风险.
- 需要一个完善的动物模型来研究雌激素治疗 (ET) 对跨性别者的心血管影响.
研究的目的:
- 为了研究雌激素治疗 (ET) 在新型跨性别女性 (TGF) 高血压大鼠模型中对心血管的影响.
- 提供关于GAHT的潜在风险和益处的见解.
主要方法:
- 雄性自发高血压大鼠接受了淋巴切除术,并接受了ET或车载治疗.
- 心声图和孤立的乳头肌肉研究评估了心脏结构和功能.
- 分析处理蛋白,氧化应激标志物和脂质资料.
主要成果:
- 丸激素缺乏减少了心脏缩,ET可以逆转这种效应,但不会改变血压.
- 在TGF大鼠中的ET导致心脏收缩率降低,并改变了处理蛋白的表达.
- ET改善了心肌氧化应激,但增加了白脂肪组织和血胆固醇水平.
结论:
- 在这种跨性别雌性老鼠模型中,雌激素治疗具有复杂的心血管风险概况.
- 研究结果表明,ET可能会恶化脂质管理和心脏收缩性,可能会影响跨性别患者的长期心血管健康.
- 进一步的研究对于优化GAHT对心血管安全至关重要.
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