肠道微生物群在癌症免疫和免疫治疗中的作用
Mingxu Xie1, Xiang Li2,3, Harry Cheuk-Hay Lau1
1Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
Cellular & molecular immunology
|August 6, 2025
概括
肠道微生物群显著影响癌症免疫力和免疫疗法的有效性. 通过诸如益生菌和便微生物群移植等干预措施调节肠道微生物,有望改善癌症治疗结果.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 人的肠道微生物群包括数万亿种对健康至关重要的微生物.
- 肠道微生物在癌症免疫力中发挥着重要作用,影响瘤生长和免疫逃避.
- 改变的肠道微生物群,通常富含病原细菌,可以促进癌症的进展.
研究的目的:
- 审查肠道微生物群对癌症先天性和适应性免疫细胞的多方面的影响.
- 探索肠道微生物群影响癌症免疫治疗疗效的机制.
- 总结针对肠道微生物群的策略,以增强癌症免疫疗法和减轻不良事件.
主要方法:
- 对调查肠道微生物群和癌症免疫力的研究进行文献综述.
- 分析致病性和有益细菌对免疫细胞群的影响.
- 评估将肠道微生物群与免疫疗法反应联系起来的机制,包括T细胞调节.
- 评估各种微生物向策略及其临床应用.
主要成果:
- 病原性细菌可以促进免疫逃避和瘤生长,而有益的共生菌则显示出治疗潜力.
- 肠道微生物群的组成通过调节T细胞等免疫细胞来影响癌症免疫疗法的疗效.
- 准肠道微生物群为改善免疫治疗结果和减少副作用提供了有希望的策略.
结论:
- 瘤微环境中的宿主微生物相互作用对癌症免疫和免疫治疗至关重要.
- 操纵肠道微生物群是一种可行的方法,可以改善癌症治疗和患者的治疗结果.
- 进一步将微生物群研究转化为临床实践对于推进癌症治疗至关重要.
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