相关实验视频

Updated: Sep 12, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

通过瘤微环境调节巨细胞极化方面的进展

Minzhi Peng¹, Yuan Zhu², Yi Hu³

¹Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, 541199, China.

Discover oncology

|August 6, 2025

概括

与瘤相关的巨细胞 (TAMs) 分为M1 (抗瘤) 和M2 (前瘤) 现型. 了解瘤微环境中的TAM两极化机制对于开发新型癌症免疫疗法至关重要.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

瘤微环境 (TME) 极大地影响瘤的进展和治疗反应.
巨细胞是TME内的关键免疫细胞,影响癌症的发展.
巨细胞分化为M1和M2表型决定了它们在瘤过程中的作用.

研究的目的:

在TME中系统地审查巨细胞两极分化到M1和M2表型.
通过瘤衍生因素阐明巨细胞两极分化的调节机制.
突出代谢重编程在瘤相关巨细胞 (TAM) 功能中的作用.

主要方法:

在TME中对巨细胞极化研究的文献综述.
对调节M1/M2分化的分子和细胞机制的分析.
检查参与TAM功能转移的代谢途径.

主要成果:

M1巨细胞通过促炎性细胞因子 (例如TNF-α,IL-12) 促进抗瘤免疫力.
M2巨细胞支持瘤生长,血管生成和通过诸如VEGF和TGF-β等因素的免疫逃避.
代谢重编程是TAM功能可塑性的关键驱动因素.

结论:

显而易见的M1和M2巨细胞表型在癌症中具有相反的作用.
瘤细胞通过代谢产物,细胞因子和ECM组件调节巨细胞极化.
准TAM代谢通路为癌症免疫治疗提供了一个有希望的策略.

关键词:

免疫细胞是免疫细胞.巨细胞是一个巨细胞.瘤微环境是一个微环境.

更多相关视频

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...