2型糖尿病患者的结构和功能大脑异常变化:基于坐标的元分析
Di He1, Zeqi Hao2, Mengqi Zhao2
1School of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Translational psychiatry
|August 6, 2025
概括
2型糖尿病 (T2DM) 与大脑的变化有关. 这项研究确定了T2DM患者常见的功能和结构性大脑变化,为该病症的神经生物学提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 医学研究 医学研究
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2DM) 是一种广泛的疾病,影响大脑功能和结构.
- 之前对T2DM相关的大脑变化的研究由于疾病变异性和有限的样本大小,产生了不一致的结果.
- 本研究通过检查T2DM中常见的神经变化来解决这些局限性.
研究的目的:
- 研究2型糖尿病患者常见的功能和结构性脑部变化.
- 确定与T2DM相关的一致的神经生物学标记.
主要方法:
- 在PubMed,Web of Science和Embase数据库中对2023年7月之前发表的研究进行了全面的文献搜索.
- 使用异型效应大小种子基d映射 (AES-SDM) 的元分析被用于评估神经活动和灰质体积 (GMV) 变化在2160名T2DM患者和2124名健康对照中.
- 激活概率估计 (ALE) 和多级核密度分析 (MKDA) 用于验证.
主要成果:
- 患有T2DM的患者表现出神经活动的改变,默认模式网络功能连接,以及视觉处理区域的GMV,包括叶,舌环和Heschl环.
- 在与感官运动功能,认知和注意力相关的大脑区域观察到额外的功能和结构变化.
- 来自ALE和MKDA元分析的发现证实了AES-SDM的结果.
结论:
- 这项研究为T2DM提供了强大的神经标志物.
- 这些发现增强了对2型糖尿病神经生物学基础的理解.
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