阿尔法和β振荡的与年龄相关的变化支持在健康的衰老中维护语义处理
Megan C Hall1, Maggie P Rempe1,2, Chloe C Casagrande1
1Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
npj aging
|August 6, 2025
概括
健康的衰老通过神经适应来保护语义处理. 大脑成像显示了与年龄相关的阿尔法和β振荡变化,特别是在左侧的圆区域,这支持保持口语流.
科学领域:
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
- 神经成像是一种神经成像.
背景情况:
- 语义处理能力通常在整个健康的衰老过程中保持不变.
- 支持老年人保留语义功能的潜在神经机制尚未得到充分理解.
研究的目的:
- 为了研究语义处理期间神经振荡中与年龄相关的变化.
- 探索大脑活动,衰老和语义任务表现之间的关系.
主要方法:
- 在154名成年人 (21-87岁) 中利用磁脑图 (MEG) 进行动态功能映射.
- 用于成像任务相关的振荡动态的beamforming.
- 应用全脑线性混合效应 (LME) 模型,分析年龄和任务条件的影响.
主要成果:
- 在多个大脑区域的α和β振荡活动中观察到显著的年龄条件相互作用.
- 这些相互作用通常表明,随着年龄的增长和/或在语义相关任务中,神经反应更强.
- 调解分析显示,左边牛α活性抑制了年龄对口语流性的负面影响.
结论:
- 神经振荡中的与年龄相关的神经生理学适应支持语义处理的保存.
- 在左侧皮质的alpha活动的特定模式对于保持随着年龄增长的语言流性至关重要.
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