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Updated: Sep 12, 2025

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通过PtdIns ((4,5) P2结合,β-arrestins对活性GPCRs进行膜域分离

Ritsuki Kuramoto1, Tatsuya Ikuta1, Carlo Marion C Carino1

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Nature chemical biology
|August 7, 2025
PubMed
概括

在β-arrestins (βarrs) 上,多个酸丁酸4,5-双酸 (PtdIns(4,5) P2) 结合点对于组装G-蛋白结合受体 (GPCR) -βarr复合体至关重要. 一个新发现的非正规部位驱动了膜域中的GPCR-βarr-PtdIns(4,5) P2复合体的快速形成.

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