在寒冷压力测试期间,疼痛和自主流出之间的关系中的性别差异
Laila A Chaudhry1,2,3, Yasmine Coovadia3, Brittany K Schwende3
1Alan Edwards Centre for Research on Pain, McGill University, 3755 University Ave, Montreal, QC, H3A 2B4, Canada.
Biology of sex differences
|August 7, 2025
概括
男人和女人对持续的疼痛有不同的同情神经系统反应. 这些发现突出了在强化疼痛期间自主机制的性别差异.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
- 疼痛研究 疼痛研究
背景情况:
- 慢性疼痛涉及交感神经系统,通过肌肉交感神经活动 (MSNA) 来衡量.
- 已知MSNA对急性疼痛的反应,但对长期疼痛的反应不太了解.
研究的目的:
- 为了调查疼痛评级和腹MSNA之间的关系,在强力冷压试验 (CPT) 期间.
- 检查对持续疼痛的自主反应中的性别差异.
主要方法:
- 在18名年轻成年人的6分钟CPT期间测量MSNA,心率 (HR) 和平均动脉血压 (MAP).
- 与自主结果同时评估口头疼痛评级.
主要成果:
- 两种性别都显示出疼痛,HR和MAP的初始增加.
- 与男性相比,女性的MSNA爆发频率 (BF) 增加得更大.
- 在男性的疼痛和HR之间,在女性的疼痛和MSNA BF之间发现了积极的相关性. 在女性的疼痛和MSNA爆发幅度之间观察到负相关性.
结论:
- 男人显示了强力疼痛和HR (横交感活动) 之间强烈的联系.
- 女性显示了强力疼痛和同情性MSNA变量之间的抵消关系.
- 在强度疼痛期间自主机制中的这些性别差异可能会告知疼痛调节策略,并解释慢性疼痛患病率差异.
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