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硫酸食纤维可以保护肠道微生物群免受抗生素的侵害

Fuqing Wu^1,2,3, Xiaoqian Annie Yu^4,5, David Angeles-Albores^4,5

¹Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. fuqing.wu@uth.tmc.edu.

|August 7, 2025

概括

富科伊丹是一种海藻多糖,可以保护有益的肠道微生物免受抗生素损害,并有助于它们的恢复. 这种海洋化合物显示出在抗生素治疗期间保持肠道健康的潜力.

科学领域:

微生物学微生物学
海洋生物技术海洋生物技术
药理学药理学是指药理学的学科.

背景情况:

抗生素对抗感染至关重要,但可以伤害有益的肠道细菌,导致失生症和相关健康问题.
目前预防抗生素诱导肠道微生物群损伤的策略有限.
了解如何在抗生素治疗期间保护大肠细菌对于保持肠道健康至关重要.

研究的目的:

调查海洋多糖体富科伊丹对肠道微生物群落的保护作用,以防止抗生素引起的损害.
探索福柯丹的保护作用背后的机制.
评估fucoidan作为辅助疗法的潜力,以在抗生素治疗期间保护肠道微生物群.

主要方法:

使用人类肠道微生物分离物和ex vivo便群体进行体外研究.
转录组分析以评估基因表达变化.
质谱测量用于研究分子相互作用.
在动物模型中进行体内实验,以评估肠道微生物恢复.

主要成果:

富科伊丹证明了对各种肠道微生物的抗生素类别的广泛保护.
富科伊丹的保护作用取决于其结构完整性,分子量和硫含量.
富科伊丹抵消了抗生素诱导的基因表达变化,并可能通过非特异性结合来抑制甲胺素.
在体内,fucoidan促进了抗生素后肠道微生物群的恢复.

结论:

富科伊丹在抗生素治疗期间显示为肠道微生物群的保护剂.
需要进一步的研究来评估fucoidan的临床疗效和安全性,确保它不会阻碍抗菌活性.

关键词:

抗生素抗生素是一种抗生素.饮食纤维的食物纤维.福科伊丹是一个子.我们的肠道微生物组.微生物社区的微生物社区.硫酸多糖化合物中的硫酸多糖.

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