相关实验视频
Updated: Sep 12, 2025

11:15
A Modified Method for Intrathecal Catheterization in Rats
Published on: February 14, 2025
1.8K
在狗的静脉区域麻醉过程中,添加阿特拉库到利多卡因溶液的效果
Marwa Abass1, Alshimaa M Farag2, Reham A Fahmy3
1Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. marwa_mossa@mans.edu.eg.
Irish veterinary journal
|August 7, 2025
概括
在狗的静脉内区域麻醉 (IVRA) 中添加阿特拉库,显著改善了镇痛和神经阻塞深度. 这种组合为骨科手术提供了增强的疼痛管理,但需要对潜在的全身毒性迹象进行监测.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 手术疼痛管理手术疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 有效的急性疼痛管理对于对狗远端肢体的骨科手术至关重要,因为它涉及广泛的软硬组织操纵.
- 静脉内区域麻醉 (IVRA) 是一种在手术过程中用于区域止痛和秋的技术.
研究的目的:
- 为了比较添加阿特拉库到基于利多卡因的IVRA对狗的抗受体,秋,心血管和血水平的影响.
- 为了评估 atracurium/lidocaine IVRA 在狗远端肢体的骨科手术中的疗效.
主要方法:
- 50只雄性蒙格尔犬接受了预先治疗和全身麻醉.
- 狗被随机分配到两个IVRA组:单独利多卡因 (LG) 或 atracurium/利多卡因组合 (LAG).
- 进行了知觉 (脚) 和神经刺激测试,并监测了生理参数和血里多卡因水平.
主要成果:
- 与利多卡因组 (LG) 相比,阿特拉克/利多卡因组 (LAG) 显示出明显较低的恶性感知得分和更深的神经阻塞.
- 在麻醉期间没有观察到生理参数的显著差异,尽管在LG后刺激和恢复期间,一些参数较高.
- 在游轮释放后,在LAG的一些狗身上观察到过多的唾液和肌肉,这表明潜在的全身影响.
结论:
- 用 atracurium 和 lidocaine 进行静脉区域麻醉是一种潜在的有效方法,用于改善狗远端四肢整形外科手术中的止痛和动脉动脉.
- 临床医生应该意识到并监测系统性毒性的潜在迹象,如过和肌肉震,在轮释放后.
相关概念视频
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
569
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
569
Local Anesthetics: Clinical Application as Epidural Anesthesia
499
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
499
Local Anesthetics: Clinical Application as Spinal Anesthesia
784
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
784
Local Anesthetics: Pharmacokinetics
852
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
852
Local Anesthetics: Common Agents and Their Applications
552
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
552
Parenteral Anesthetics: Overview
199
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
199

