发展治疗和下腺癌的存活率:一个单中心研究
Chia-Fan Chang1,2, Pen-Yuan Chu1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|August 7, 2025
概括
不断发展的外科手术技术,包括横口激光微手术 (TLM),改善了下支状细胞癌 (HPSCC) 患者的生存率和喉保存. 随着时间的推移,治疗转换显示复发率降低,结果更好.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 头部和部手术 头部和部手术
- 在瘤学瘤学.
背景情况:
- 低支柱状状细胞癌 (HPSCC) 往往呈现出晚期疾病和不良预后.
- 对于HPSCC的传统激进手术显著影响生活质量.
- 目前的治疗趋势正在远离初级手术治疗,尽管有显著的长期不良影响.
研究的目的:
- 在一个医疗中心检查HPSCC患者的治疗结果.
- 评估不断变化的治疗方式对生存和喉保存的影响.
- 分析不同时期治疗方法的变化.
主要方法:
- 在2004年至2012年期间接受治疗的167名HPSCC患者的回顾性分析.
- 研究期间分为三个区块 (2004-2006,2007-2009,2010-2012),以评估治疗演变.
- 评估瘤复发,喉功能和跨期生存率.
主要成果:
- 随着时间的推移,越来越多地使用跨口激光微手术 (TLM).
- 喉保存率从14%上升到41%,瘤复发率从48%下降到31%.
- 基于手术的治疗显示了与化疗放射治疗可比的生存率,五年总生存率从32%增加到55%.
结论:
- 手术技术,放射治疗,化疗和治疗方案的进步改善了HPSCC的结果.
- 横腔激光微手术 (TLM) 对于早期阶段有效,并选择先进的HPSCC,保持喉功能.
- 不断发展的治疗策略提高了HPSCC患者的生存率和喉保存.
更多相关视频
相关概念视频
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Esophageal Varices-II: Clinical Features and Management
140
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
140
Cancer Survival Analysis
455
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
455
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Barrett Esophagus-II: Clinical Manifestations and Management
301
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
301


