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前额叶皮层对食物刺激的招募在超重/肥胖和暴饮暴食障碍中不同
Jennifer Svaldi1,2, Betti Schopp2,3, Philipp A Schroeder1,2
1Department of Clinical Psychology and Psychotherapy, University of Tuebingen, Tübingen Center of Mental Health (TüCMH), Tübingen, Germany.
概括
患有暴饮暴食障碍 (BED) 和超重个体的个体在食物抑制任务期间在前额区域显示出不同的大脑活动模式. 这些发现突显了这些群体之间神经控制机制的差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 暴饮暴食障碍 (BED) 在表型上与没有BED的超重不同.
- 在食物抑制期间,BED和超重个体都表现出前额低活化.
- 在食物抑制期间对照区域的神经差异尚未完全理解.
研究的目的:
- 在与食物相关的抑制过程中,研究右背侧前额叶皮层 (DLPFC) 和右下额叶 (IFG) 中的差异神经激活.
- 在刺激处理过程中检查轨道前皮层 (OFC) 的活动.
- 为了比较患有BED的个体的神经特征,没有BED的超重 (OWC) 和正常体重 (NWC) 的控制.
主要方法:
- 功能近红外光谱学 (fNIRS) 用于测量大脑活动.
- 参与者 (BED,OWC,NWC) 用食物和非食物刺激完成了Go/No-Go和刺激降解任务.
- 使用了对比的任务和刺激顺序.
主要成果:
- 与NWC相比,在BED和OWC组中都观察到前额部低活化.
- 在Food-NoGo条件下,BED组在IFG中表现出低活化.
- 在OWC组在食品-NoGo条件下显示了DLPFC的低活化.
结论:
- 患有BED和超重的个体在食物抑制期间表现出明显的前额叶低活性模式.
- 建议在BED和超重个体中对DLPFC和IFG进行不同的招募.
- 这些发现有助于了解暴饮暴食和超重的神经支.
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