对药物向宁- ангиотензин系统和全球认知在衰老中的比较
Claudene J George1, Kay Thwe Kyaw1, Charles B Hall2
1Montefiore Medical Center, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Journal of Alzheimer's disease : JAD
|August 7, 2025
概括
列宁- ангиотензин系统 (RAS) 药物,如 ангиотензинII受体阻断剂 (ARB) 和 ангиотензин转化酶抑制剂 (ACEI),显示在维持认知功能方面具有潜力. ARBs可能会支持整体认知,而ACEI可能会增强工作记忆,特别是在没有高血压的人群中.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压 (HTN) 是阿尔茨海默病 (AD) 和痴呆症的重要危险因素.
- 包括ACEI和ARB在内的renin-angiotensin系统 (RAS) 药物正在研究其减缓认知衰退的潜力,但证据是混合的.
研究的目的:
- 为了比较ARB,ACEI和非RAS药物使用者的9年全球认知变化.
- 研究这些药物类别对特定认知领域以及患有高血压和没有高血压的个体的影响.
主要方法:
- 利用了来自Rush记忆和衰老项目的数据 (2019年参与者,1997-2006年).
- 通过19个认知测试的复合z分数评估全球认知.
- 使用协差分析 (ANCOVA) 来比较结果,根据基线认知和其他因素进行调整.
主要成果:
- 在9年后,ARB使用者比ACEI或非RAS使用者表现出更好的全球认知结果的趋势,尽管在统计学上并不显著.
- 与非RAS用户相比,ACEI使用者在工作记忆中表现出显著的改善.
- 在没有HTN的参与者中,与非RAS使用相比,ACEI使用与认知衰退显著减少有关.
结论:
- ARBs可能为全球认知功能提供好处,而ACEI则显示出改善工作记忆等特定认知领域的前景.
- 需要进一步的研究来证实这些发现,并探索这些药物的血脑屏障透等因素.
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