单边刺激背侧状体减弱了目标导向行动的作用
Genevra Hart1, Billy Chieng1, Bernard W Balleine1
1The Decision Neuroscience Lab, UNSW Sydney, Sydney, Australia.
The European journal of neuroscience
|August 7, 2025
概括
刺激大鼠的背侧条纹体 (DLS) 干扰了目标导向行为,表明它在习惯形成中的作用,而不是直接的运动控制. 这与背中条体 (DMS) 形成鲜明对比.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 系统神经科学 系统神经科学
背景情况:
- 众所周知,背中条体 (DMS) 和背侧条体 (DLS) 控制着不同的动作类型:分别是目标导向和习惯性.
- 以前的研究表明,DMS刺激增强了与刺激相反的目标导向行动,与奖励历史进行扩展.
研究的目的:
- 通过评估其对目标导向行为的影响,调查背侧条纹体 (DLS) 刺激是否增强习惯控制.
- 在动作选择和控制中区分DMS和DLS的功能角色.
主要方法:
- 鼠被训练在一个双杆任务,以建立目标导向的控制.
- 在结果值和结果介导的恢复测试期间,应用了单边hM3D DREADDs诱导的DMS或DLS刺激.
- 行为反应分析了目标导向控制和响应偏差的变化.
主要成果:
- DMS刺激没有影响在值或恢复测试中的选择.
- DLS刺激取消了目标导向控制,大大降低了对ipsilateral和contralateral杆结果值的敏感性.
- 在恢复响应过程中,DLS刺激减弱了恢复,并诱导了偏差远离反边杆.
结论:
- 脊侧条纹体 (DLS) 对于选择与刺激-反应习惯相关的运动程序至关重要,而不是直接驱动运动输出.
- 这些发现提升了我们对DMS和DLS在调解不同形式的行为控制中的不同角色的理解.
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