超越左脑半球:健康衰老中的双边语言横向化及其临床影响
David Toloza-Ramirez1,2, Rodrigo Santibañez3, Leonardo Arraño-Carrasco4
1Interdisciplinary Center for Neuroscience, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Frontiers in aging neuroscience
|August 7, 2025
概括
健康的老年人表现出对语义和语音处理的双边大脑激活,这表明了补偿机制. 下额回形在衰老期间在语音流方面发挥着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 语言学的语言学.
背景情况:
- 年轻的成年人表现出左侧化语言网络用于语义和语音处理 (SP和PP).
- 在健康的老年人中,SP和PP神经机制的与衰老相关的变化尚未得到充分理解.
- SP和PP被认为是病态衰老的潜在认知标志物.
研究的目的:
- 研究老年西班牙语成年人的语言横向化动态.
- 将大脑激活模式与SP和PP任务中的行为表现相关联.
- 了解老化中的语言处理的神经基础.
主要方法:
- 对28名智利老年健康成年人 (平均年龄67.7岁) 进行了fMRI扫描.
- 参与者完成了语义和语音任务,以及语言表现评估 (ScreeLing,口头流利).
- 固定效应和标准回归分析被用来检查群体差异和大脑行为关联.
主要成果:
- SP和PP都显示在下额头 (IFG) 和上状中双边激活.
- 左下垂体环也表现出激活.
- 语义流性与直角环和IFG pars opercularis激活相关;语音流性与双边IFG pars orbitalis激活相关.
结论:
- 健康的老年人为SP和PP招募双边语言网络,可能是由于衰老中的补偿机制.
- IFG pars orbitalis可能在语音流方面发挥着特定的作用,超出了传统的PP协会.
- 需要进一步的研究来阐明 IFG pars orbitalis 对老年人声学表现的贡献.
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