半元素与聚合物配方用于重症患者的肠道营养:多中心集群随机对照试验的二次分析
Wei Wei1, Wen Lu1, Guofeng Chen1
1Department of Emergency Medicine, Yangming Hospital Affiliated to Ningbo University (The People's Hospital of Yuyao City), Yuyao, Zhejiang, China.
Frontiers in nutrition
|August 7, 2025
概括
半元素肠道营养 (EN) 在接受胃食的重症患者中减少了腹痛. 与聚合物配方相比,这种配方没有增加腹风险,改善了胃肠道耐受性.
科学领域:
- 关键护理医学 关键护理医学
- 临床营养学 临床营养学
- 胃肠病学 胃肠病学
背景情况:
- 肠道营养 (EN) 对重症患者至关重要.
- 理论上,半元素配方可以提高胃肠道的耐受性.
- 人们担心半素食配方增加了腹风险,特别是后皮洛里克养.
研究的目的:
- 在接受胃食的重症患者中,评估半元素EN与聚合物EN的疗效.
- 评估对胃肠道耐受性的影响,特别是不耐受性相关的症状.
主要方法:
- 一个多中心,集群随机对照试验 (NEED试验) 的后期分析.
- 纳入标准:重症患者在第一周内接受胃内肠道独家治疗.
- 倾向分数匹配 (PSM) 用于控制通过指向非循环图 (DAG) 识别的混因子.
主要成果:
- 分析了516对匹配的对.
- 腹部膨胀/疼痛发生率在半元素组明显较低 (9.1%对13.8%,RR 0.66,p=0.027).
- 两组之间没有发现恶心/吐,吸血或腹发病率的显著差异.
结论:
- 通过胃部接入的半元素EN可减少重症患者的腹部张张/疼痛.
- 与聚合物配方相比,半元素配方并没有增加腹的发生率.
- 这些发现表明,在特定的胃养环境中,半元素配方可能有好处.
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