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结合疗法的比较有效性和复发性:一个系统的审查和网络元分析

Alexandra F Chandra¹, Jenisa Kamayana², Narottama Tunjung¹

¹From the Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Plastic and reconstructive surgery. Global open

|August 7, 2025

概括

组合疗法,如三氨酸 (TAC) 加上5-甲 (5-FU) 与激光或支臂疗法,和TAC与白素,显示优越的 keloid 管理. 这些多式疗法比单独的TAC更有效地减少复发.

科学领域:

皮肤病学皮肤病学
医学研究医学研究
临床试验中的临床试验.

背景情况:

由于高复发率和患者反应的多样性,状体的管理存在挑战.
越来越多地探索组合疗法,以改善 keloid 治疗结果.

研究的目的:

为了确定最有效的结合疗法为 keloids.
为了确定哪些组合产生最低的复发率.

主要方法:

进行了一个网络元分析 (NMA).
分析了22个随机对照试验 (RCT) 的数据,其中包括1398例病例.
在Cochrane,PubMed和Scopus数据库中进行了搜索.

主要成果:

三氨酸 (TAC) 和5-Fluorouracil (5-FU) 与脉冲染色激光 (PDL) 或支臂治疗的组合显示出明显更高的疗效,而不是TAC单一治疗.
TAC + 5-FU + PDL (RR 2.98) 和TAC + 5-FU (RR 1.43) 显示了提高的疗效.
最低的复发率被观察到与TAC + 血红素 (RR 0.04) 和TAC + 5-FU + 支架疗法 (RR 0.23).

结论:

组合疗法,特别是TAC + 5-FU与PDL或支架疗法,以及TAC + 布莱米辛,在 keloid 管理方面比TAC 单一疗法更有效.
这些发现支持量身定制的多模式治疗策略,以实现最佳的 keloid 管理和患者结果.

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