通过微滴校准量化激光诱导气溶的量化和使用LA-ICP-TOFMS对矩阵效应的调查
Tobias Schöberl1, Mirjam Bachmann1, Detlef Günther1
1Laboratory of Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich 8093 Zurich Switzerland.
Journal of analytical atomic spectrometry
|August 7, 2025
概括
单分散微滴使激光除诱导合等离子体飞行时间质谱法 (LA-ICP-TOFMS) 中的准确非矩阵匹配量化成为可能. 这种方法克服了矩阵效应,为各种地质和有机样本提供可靠的元素分析.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
- 地质化学 地质化学
背景情况:
- 矩阵匹配校准是激光切除感应合等离子体质谱法 (LA-ICP-MS) 的常见挑战.
- 现有的方法在各种样本矩阵中难以准确量化,特别是对于未经认证的元素.
- 了解血内行为对于改善LA-ICP-MS量化至关重要.
研究的目的:
- 在LA-ICP-TOFMS中研究单分散微滴对非矩阵匹配量化的有效性.
- 与溶液雾化相比,分析微滴中信号抑制效应.
- 为了评估微滴和激光诱导的气溶的在等离子体内的行为.
主要方法:
- 通过落下管引入的微滴,用于LA-ICP-TOFMS分析.
- 使用主要地质元素 (Al,Si,Ca,Ti,Fe) 研究信号抑制.
- 获取辐射扩散配置文件以评估在等离子体中的滴滴和气溶行为.
主要成果:
- 微滴信号抑制模式与溶液雾化不同,并不能通过质量负荷或氧化物形成来解释.
- 微液滴和激光诱导的气溶的在血扩散形状显示,在半最大时 (FWHM) 的全宽度重叠.
- 微滴滴校准在认证的参考材料和凝标准中实现了低于±20%的相对偏差.
结论:
- 单分散微滴适合在LA-ICP-TOFMS中进行非矩阵匹配校准.
- 这种方法提供了准确的量化,特别是对于缺乏认证参考材料的元素.
- 微滴校准比使用矩阵匹配标准的传统外部校准提供了改进.
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