用捐赠者与伴侣精子构思的怀孕中的产科和周产期结局:系统性审查和元分析
Junjie Liu1, Yanpeng Dai2, Zuozhe Song1
1Henan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in endocrinology
|August 7, 2025
概括
在不孕症治疗中使用捐赠精子显示出更好的怀孕率,但具有更高的孕前和怀孕引起的高血压风险. 需要进一步的研究来了解这些结果并开发干预措施.
科学领域:
- 生殖医学 生殖医学
- 产科 产科 产科 产科 产科
- 遗传学 遗传学 是一个
背景情况:
- 男性不孕症占病例的30-40%,捐赠精子是严重病例或遗传疾病的关键解决方案.
- 人们担心精子DNA受损,氧化压力以及冷保存的捐赠精子对胚胎发生的表观遗传影响.
- 之前对捐赠者与伴侣精子产科和围产期结果的研究是不一致的.
研究的目的:
- 系统地比较捐赠精子和伴侣精子之间的产科和产周结果.
- 为辅助生殖技术的临床决策提供基于证据的指导.
- 通过元分析分析现有研究的数据.
主要方法:
- 在2024年12月之前对Embase,PubMed,Scopus,Web of Science和CNKI的系统文献搜索.
- 包括关于产科和围产期结果的研究,不论受孕方法如何.
- 随机效应模型用于组合相对风险 (RRs) 和95%置信区间 (CI) 由于异质性.
主要成果:
- 捐赠精子与更高的临床怀孕率 (RR 1.27) 和更低的流产 (RR 0.91) 和非常早产 (RR 0.88) 相关.
- 与捐赠精子一起观察到妊娠前 (RR 1.35) 和妊娠引起的高血压 (RR 1.19) 的风险增加.
- 对于妊娠糖尿病,宫外妊娠,胎盘问题,出生体重变化或围产死亡率没有发现显著差异.
结论:
- 捐赠精子可以改善妊娠结果,但会增加特定高血压疾病的风险.
- 进一步的研究对于阐明这些观察到的风险的潜在机制至关重要.
- 有针对性的干预措施可能是必要的,以减轻与捐赠精子受孕相关的不良结果.
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