血清氨酸在老年人群中增加全因死亡率
Yuhong Dai1, Yong Zhang1, Yue Zhang1
1Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical College, Huai'an, China.
Frontiers in endocrinology
|August 7, 2025
概括
血清氨酸水平升高与老年人全因死亡风险较高有关. 这一发现表明,氨酸可能是预测这一群体死亡风险的有用生物标志物.
科学领域:
- 老年学是一门学科.
- 生物化学 生化学
- 流行病学 流行病学
背景情况:
- 氨基酸,特别是分支链和芳香类型,与代谢和心血管疾病有关.
- 特定氨基酸与死亡风险之间的关联,特别是在老年人群中,需要进一步研究.
研究的目的:
- 为了研究血清氨基酸水平 (白氨酸,单氨酸,氨酸,氨酸,氨酸,氨酸,氨酸) 和因任何原因或心血管死亡率之间的相关性.
- 评估血清氨基酸在预测老年人死亡率方面的预后价值.
主要方法:
- 一组1,238名年龄≥60岁的个人被跟踪了9年.
- 在基线测量了五种氨基酸的血清水平.
- 考克斯回归和细灰次分布危险分析被用于评估死亡风险,预后值使用C指数和净重新分类改进 (NRI) 进行评估.
主要成果:
- 血清氨酸水平与全因死亡风险有显著的关联.
- 经过对混因子进行调整后,较高的血清氨酸四分位数与所有原因死亡率的增加有关 (HRs从1.31到2.18不等).
- 包括血清氨酸水平改善了所有原因死亡率的预测模型 (C指数从0.773增加到0.787,NRI = 0.267).
结论:
- 血清氨酸水平升高与中国老年人因各种原因死亡的风险增加独立相关.
- 血清氨酸可以作为一个有价值的生物标志物来预测死亡风险在这个人口.
- 进一步的研究可以探索这种关联背后的机制.
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