评估扩展器幻觉短视硬和糖尿病中的微循环:剪切波弹性学和对比增强超声波
Fuqiang Yan1, Mingli Cai1, Meirong Li2
1Department of Ultrasound Medicine, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital), Quanzhou, China.
Frontiers in endocrinology
|August 7, 2025
概括
非侵入性的超声波技术,剪切波弹性图 (SWE) 和对比增强超声波 (CEUS),可以检测扩展器幻觉大脑肌肉的早期微血管变化. 这些方法有助于评估糖尿病足并发症风险,并指导干预.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病足部并发症是导致疾病和截肢的主要原因,主要是由于微血管功能障碍.
- 早期检测肌肉中的微循环和生物机械变化,如扩展器幻觉 (EHB),对于风险分层至关重要.
- 目前用于量化这些变化的非侵入性工具是有限的.
研究的目的:
- 评估剪切波弹性图 (SWE) 和对比增强超声波 (CEUS) 在检测EHB肌肉中的微血管和生物机械变化的有效性.
- 评估SWE和CEUS的诊断准确性和可重复性,以确定2型糖尿病中微血管并发症.
主要方法:
- 一项涉及90名参与者的横截面研究:健康的对照组,没有并发症的2型糖尿病 (T2DM) 和带有微血管并发症 (MC) 的T2DM.
- SWE测量了EBH硬度 (Emean),而CEUS评估了输液量 (ΔAT, ΔPI).
- 诊断准确性通过ROC分析确定,可复制性通过ICC.
主要成果:
- 在不同组中,EBH硬度 (Emean) 逐渐增加 (P < 0.01).
- 与对照组 (P < 0.01) 相比,具有MC的T2DM显示了延长的透毛细管过渡时间 (ΔAT) 和降低的净增强强度 (ΔPI).
- ΔAT,Emean和ΔPI在检测MC方面表现出高的诊断准确性 (AUC>0.93),具有很好的可重现性 (ICC>0.80).
结论:
- SWE和CEUS为早期糖尿病微血管并发症提供可靠的非侵入性生物标志物.
- EHB肌肉对硬度和 perfusion 变化的敏感性使其对糖尿病足风险评估具有价值.
- 这些超声波技术可以指导及时干预,以防止和截肢.
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