探索健康的上下文社会决定因素与COVID-19的发生和住院之间的关系
Aokun Chen1, Yunpeng Zhao2, Yi Zheng3
1Department of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL 32611, USA.
概括
这项研究探讨了健康的社会决定因素 (SDoH) 如何影响COVID-19发生和住院治疗. 某些SDoH因素,如医院床位可用性和空置物业百分比,与COVID-19发生有关,而其他因素,如农民市场,与住院有关.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 关于健康的社会决定因素 (SDoH) 和COVID-19结果的先前研究受到数据表示和范围的限制.
- 有关上下文SDoH与COVID-19发生和严重程度之间的具体关系存在一个知识差距.
研究的目的:
- 调查199个健康背景社会决定因素 (SDoH) 与COVID-19发生率和住院治疗之间的关联.
- 利用来自大型临床研究网络 (CRN) 的电子健康记录 (EHR) 进行全面分析.
主要方法:
- 将11个领域的199个上下文SDoH因素与来自主要国家以患者为中心的临床研究网络 (PCORnet) 的EHR数据联系起来.
- 分析了佛罗里达州15,890名COVID-19患者和63,560名匹配对照的数据 (2020年1月至2021年5月).
- 采用了经过修改的两相多重线性回归方法,类似于全暴露组关联 (ExWAS) 研究,分析了86个选定的SDoH变量.
主要成果:
- 六个上下文SDoH变量与COVID-19发生有关,包括医院床位的可用性,空置物业的百分比,高尔夫球场密度和少数民族人口的百分比.
- 三个上下文SDoH变量与COVID-19住院有关:农民市场的可访问性,低通道区域和宗教设施密度.
- 在分析中对种族,种族和并发性疾病进行了调整.
结论:
- 这项研究为健康的上下文社会决定因素 (SDoH) 与COVID-19发生率和住院治疗之间的关系提供了新的见解.
- 这些发现突出了与COVID-19结果相关的特定环境和社区因素,使用了大量的EHR数据集.
- 未来的研究将专注于评估SDoH对COVID-19结果的因果关系.
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