舒吉配方通过抑制NF-κB和ERK MAPK信号通路来改善流感A病毒引起的急性肺损伤
Biao Lei1,2,3, Wenbo Huang4, Wei Peng1
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Infection and drug resistance
|August 7, 2025
概括
舒吉配方 (SFJBF) 通过减少肺炎和保护病毒感染,有效治疗流感. 它通过通过关键信号通路抑制过度活跃的免疫反应来起作用.
科学领域:
- 传统中国医药 传统中国医药
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 舒洁配方 (SFJBF) 是一种治疗急性呼吸道感染的传统药物.
- 流感是一个重大的公共卫生挑战,需要新的治疗策略.
研究的目的:
- 调查SFJBF在治疗流感的潜在机制.
- 评估SFJBF对流感病毒感染的治疗效果和保护机制.
主要方法:
- 网络药理学被用来阐明SFJBF的作用机制.
- 在体内研究评估了SFJBF对小鼠肺损伤,体重和炎症的影响.
- 使用RAW264.7细胞和分离的中性粒细胞进行的体外试验评估了SFJBF的抗炎性质.
主要成果:
- SFJBF减轻了流感诱导的肺损伤,保护了体重,并减少了诸如化学因子和细胞因子等炎症标志物.
- SFJBF抑制了中性粒细胞和炎症性单细胞在肺中的透.
- SFJBF抑制了关键信号通路,包括NF-κB和ERK MAPK,其活性成分减少了活性氧物种 (ROS) 的产生.
结论:
- 通过通过NF-κB和ERK MAPK通路调节免疫反应,SFJBF显示出强大的抗流感治疗效果.
- SFJBF可改善病毒引起的肺损伤,可以被认为是流感治疗的有前途的药物.
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