结肠病和微生物群:是个性化生物干预的时间了吗? 一个范围审查审查
Francesco Valitutti1,2, Elena Cavalli3, Beatrice Leter4
1Pediatrics Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
BMJ nutrition, prevention & health
|August 7, 2025
概括
全球乳病 (CeD) 的患病率正在上升,可能与肠道微生物群变化有关. 研究表明,特定的益生菌可能有助于控制CeD症状并改善恢复.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 结肠病 (CeD) 的患病率在全球范围内不断增加,反映了其他免疫媒介疾病的趋势.
- 环境因素,特别是肠道微生物群的干扰,被假设为这种增加做出了贡献.
研究的目的:
- 审查目前关于微生物群变化与CeD发病之间的关系的证据.
- 探索微生物群在CeD病变发生中的作用.
- 总结对CeD的潜在生物基治疗干预措施.
主要方法:
- 在谷歌学者,PubMed,EMBASE和Scopus上进行了全面的文献搜索.
- 关键词包括"乳病"与"微生物群"",微生物群"",前生物"",益生菌"",共生菌"和"后生物"相结合.
- 采用了系统审查过程,将1779篇最初的文章过到131个相关的参考文献.
主要成果:
- 有大量关于CeD患者微生物群变化的文献.
- 微生物群变化与CeD发病之间的因果关系尚不清楚.
- 有限的研究表明,特定益生菌菌株在缓解CeD症状和帮助恢复方面具有潜在的益处.
结论:
- 虽然微生物群的变化在CeD中得到了记录,但它们在疾病发病与后果中的作用需要进一步调查.
- 特定的益生菌干预措施对症状管理,减少炎症和改善CeD的结果有希望.
- 需要进一步的研究来阐明CeD微生物群调节的精确机制和治疗潜力.
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