2型糖尿病患者中微量营养素缺乏的负担:系统性审查和元分析
Daya Krishan Mangal1, Nida Shaikh2, Himanshu Tolani2
1IIHMR, Jaipur, India.
BMJ nutrition, prevention & health
|August 7, 2025
概括
多种微量营养素缺乏影响了近一半的2型糖尿病患者,维生素D缺乏是最常见的. 患有2型糖尿病的女性出现较高的缺乏率,突出显示了全球严重的健康问题.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 微量营养素缺乏在全球范围内普遍存在,特别是在南亚和撒哈拉以南非洲.
- 这些缺陷可以影响葡萄糖代谢和胰岛素信号传递,可能有助于2型糖尿病 (T2D) 的发展和进展.
- 以前的研究往往集中在单个微量营养素上,导致关于T2D患者整体负担的相互矛盾的证据.
研究的目的:
- 在2型糖尿病患者中对多种微量营养素缺乏的负担进行全面评估.
- 通过同时检查广泛的微量营养素来综合和解决先前研究中的相互矛盾的证据.
主要方法:
- 按照PRISMA 2020指南和"柯克兰手册"进行系统审查.
- 在多个数据库 (Embase,PubMed,Scopus等) 中进行广泛的文献搜索. 和灰色文学.
- 从132项涉及52,501名参与者的研究中提取数据,并使用R V.4.3.2.2.进行统计分析.
主要成果:
- 在T2D患者中,多种微量营养素缺乏的综合患病率为45.30%.
- 与男性相比,患有T2D的女性表现出较高的综合缺陷患病率 (48.62%).
- 维生素D缺乏是最常见的 (60.45%),其次是 (41.95%). 在服用甲胺的患者中,B12缺乏率更高.
结论:
- 微量营养素缺乏在2型糖尿病患者中很常见,而维生素D缺乏是最常见的.
- 患有T2D的女性更容易出现微量营养素缺乏.
- 由于潜在的选择偏差,应谨慎解释基于医院的研究结果;地理差异受饮食,生活方式和文化因素的影响.
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