高强度螺旋流:冠状动脉血动力学中的双刃剑
Chi Shen1, Mingzi Zhang1,2, Hamed Keramati1
1School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales, Australia.
Royal Society open science
|August 7, 2025
概括
冠状动脉中的螺旋流影响了血液流动模式. 这项研究揭示了螺旋流既可以减少保护性低剪压,又可以增加有害的高剪压,影响动脉样硬化发展和斑块脆弱性.
科学领域:
- 心血管科学 心血管科学
- 生物医学工程 生物医学工程
- 血液动力学 血液动力学
背景情况:
- 在人类冠状动脉中螺旋式血流的作用尚未完全理解.
- 螺旋流对动脉样硬化和心血管事件的影响需要进一步调查.
研究的目的:
- 为了研究螺旋流和血液动力学描述器在患者特定的冠状动脉的影响.
- 分析螺旋流强度和狭窄和非狭窄动脉中的内皮切割应力之间的关系.
主要方法:
- 使用了冠状动脉自动细分 (ASOCA) 数据集.
- 分析了39个特定于患者的左冠状动脉树 (20个非狭窄的,19个狭窄的).
- 相关的绝对螺旋流强度 (h2) 与时间平均内皮切削应力 (TAESS).
主要成果:
- 较高的螺旋流强度 (h2) 与所有段的TAESS增加相关,不论狭窄.
- 在狭窄的动脉中,高h2区域与低TAESS (<0.5Pa) 的区域减少和高TAESS (>4.71Pa) 的区域增加有关.
- 螺旋流对TAESS模式的影响在非狭窄和狭窄的冠状动脉中都显著.
结论:
- 冠状动脉中的螺旋流并不是对动脉样硬化的均保护.
- 它可以减轻与斑块发育相关的低TAESS,但也会加剧与斑块脆弱性和急性事件相关的高TAESS.
- 这些发现重新定义了对螺旋式血流在心血管动脉样硬化疾病中的作用的理解.
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