免疫球蛋白替代疗法用于预防常见可变免疫缺陷的感染的现实世界模式:一个多中心全国性研究
Pedro Moral Moral1,2, Victor Garcia-Bustos1,3, Héctor Balastegui-Martin1,2
1Primary Immunodeficiencies Unit, Department of Internal Medicine, University and Polytechnic Hospital La Fe, Valencia, Spain.
在西班牙常见变性免疫缺陷 (CVID) 患者中,皮下免疫球蛋白替代疗法 (SCIg) 的使用正在增加,提供了更大的自主权. 然而,静脉注射免疫球蛋白 (IVIg) 仍然占主导地位,特别是在二级医院.
科学领域:
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫球蛋白替代疗法 (IgRT) 对常见变性免疫缺陷 (CVID) 患者至关重要.
- 静脉注射 (IVIg) 和皮下注射 (SCIg) 免疫球蛋白都有效.
- SCIg提供了诸如系统性副作用减少和患者自主权增加等优势,但在某些地区,其使用是有限的.
研究的目的:
- 为了评估西班牙CVID患者IgRT使用的现实世界模式.
- 在临床实践中分析影响IVIg和SCIg之间选择的因素.
- 评估目前西班牙SCIg与IVIg的使用情况.
主要方法:
- 这是一项使用GTEM-SEMI-CVID注册表数据进行的横截面多中心研究.
- 包括212名在西班牙接受IgRT的成年CVID患者.
- 收集了人口,临床和免疫学数据,比较IVIg和SCIg组.
主要成果:
- 41.5%的患者使用SCIg,主要是年轻人在家接受治疗.
- 58.5%的患者使用IVIg,老年人的比例更高.
- 在IVIg和SCIg组之间没有观察到感染率,自身免疫性并发症,剂量或IgG最低水平的显著差异.
结论:
- 在过去的十年中,SCIg在西班牙的使用量有所增加,但IVIg仍然更常见.
- 患者的年龄是选择IVIg和SCIg之间的重要因素.
- 优化SCIg访问,特别是在二级护理环境中,对于改善患者自主性和结果至关重要.
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