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饮食多补充剂对COPD的有效性和安全性:系统性审查和元分析

Dongsheng Wu^1,2, Yuang Dong¹, Dongyang Zhang¹

¹Anhui University of Traditional Chinese Medicine, Hefei, China.

Frontiers in immunology

|August 7, 2025

概括

饮食中的多在慢性阻塞性肺病 (COPD) 管理方面表现有前途,黄素和沙利德化物改善肺功能并减少炎症. 然而,疗效因多类型而异,需要个性化治疗方法.

科学领域:

肺部医学肺部医学
营养科学营养科学
药理学药理学是指药理学的学科.

背景情况:

饮食中的多具有抗氧化和抗炎性质,有利于慢性阻塞性肺病 (COPD).
潜在的机制包括调节氧化还原稳定,抑制NF-κB炎症途径,改善呼吸功能.
现有的临床证据异质,需要对标准化多补充剂进行严格评估.

研究的目的:

系统地评估COPD患者标准化口服多补充剂的临床疗效 (GOLD II-III阶段).
分析先进的生物标志物和肺功能轨迹.
为COPD管理提供个性化的营养干预措施提供证据.

主要方法:

在数据库 (PubMed,Cochrane,Medline,CNKI) 进行系统的文献搜索,截至2024年12月26日.
包括随机对照试验 (RCT) 评估八种特定的多.
使用RevMan 5.3软件进行的元分析,包括质量评估和数据提取.

主要成果:

库尔库改善了FEV1并降低了缩血压.
沙利德化物减少了血栓性标志物,炎症因子 (TNF-α) 和症状评分 (CAT).
复星下调血清TNF-α和IL-8;安东素可能会对肺功能产生负面影响;其他多醇的疗效有限.

结论:

聚醇在COPD中的有效性是成分特异性的,黄素和沙利德化物显示出治疗潜力.
安西的潜在不良影响凸显了解决成分异质性的必要性.
推使用黄素和坦辛作为辅助疗法,强调个性化的营养,而不是盲目的补充.

关键词:

慢性阻塞性肺病慢性阻塞性肺病库尔库明是一种黄素.饮食中的多醇.这是一个元分析.沙利德化物是什么

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