基于TIL的细胞产品用于癌症免疫疗法的生成:当前的见解和挑战
1Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, 119435 Russia.
Acta naturae
|August 7, 2025
概括
瘤透淋巴细胞 (TILs) 通过扩大患者的T细胞提供了有前途的癌症免疫疗法. 目前面临的挑战包括为更广泛的应用标准化TIL生产.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 瘤透淋巴细胞 (TILs) 是瘤内的T细胞,驱动适应性抗瘤免疫力.
- TIL治疗涉及患者衍生的TILs的活体扩张和再输注,以增强对癌症的免疫反应.
- 最近批准了一种基于TIL的黑色素瘤药物,突显了这种方法的治疗潜力.
研究的目的:
- 审查基于TIL的癌症免疫治疗的概念和阶段.
- 识别和讨论TIL生成和应用中的当前挑战.
- 探索未来改善TIL治疗效率和可访问性的方向.
主要方法:
- 对TILs和癌症免疫疗法的现有文献的审查.
- 分析生成TIL蜂产品的过程.
- 在TIL生产中识别技术和后勤障碍.
主要成果:
- TIL疗法是一种可行的免疫疗法,最近取得了进展和批准.
- 仍然存在重大挑战,包括缺乏用于TIL隔离,扩展和冷保存的标准化协议.
- 目前的方法面临着TIL文化生成的效率,复杂性和持续时间的问题.
结论:
- 在治疗固体瘤方面,TIL疗法具有很大的前景,包括那些对其他治疗方法耐药的瘤.
- 标准化和提高TIL生产效率对于更广泛的临床采用至关重要.
- 需要进一步的研究来克服现有的局限性,并扩大基于TIL的免疫疗法的应用.
更多相关视频
相关概念视频
Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
Cancer Vaccines
510
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
510
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K


