分析技术用于确定类醇和布洛芬组合
Imad O Abu Reid1, Sayda M Osman1, Somia M Bakheet1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International University of Africa, Khartoum, Sudan.
Journal of analytical methods in chemistry
|August 7, 2025
概括
本综述汇编了布洛芬 (IBU) 和青 (PAR) 固定剂量组合的分析方法. 它强调了高性能液体染色学 (HPLC) 和紫外线/可见光谱光学作为IBU/PAR量化的主要技术.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于协同作用,布洛芬 (IBU) 和 (PAR) 的固定剂量组合 (FDC) 已被广泛用于治疗疼痛.
- 通过抑制COX酶,IBU提供止痛和抗炎作用,而PAR提供中央止痛.
- 对IBU/PAR FDCs的分析方法缺乏全面的审查.
研究的目的:
- 系统地审查和编制分析方法,以确定散装和制药配方中的布洛芬和.
- 为研究人员和专业人士提供一个有价值的资源,用于分析IBU/PAR FDCs的技术.
- 确定用于IBU/PAR量化最常见的分析技术.
主要方法:
- 在主要科学数据库 (Science Direct,Springer Link,PubMed,Scopus,Google Scholar) 进行系统的文献搜索.
- 识别和编制分析方法,包括HPLC,GC,HPTLC,UV/可见光谱光度计,FTIR和MEKC.
- 对IBU/PAR测定方法报告频率的分析.
主要成果:
- 编制了FDC中IBU和PAR量化分析方法的综合清单.
- 高性能液体染色学 (HPLC) 和紫外线/可见光谱光度计是最常见的方法,每种方法在37.9%的研究中使用.
- 其他确定的方法包括GC,HPTLC,FTIR和MEKC.
结论:
- 这次审查整合了IBU/PAR FDCs的最新分析方法.
- 它作为未来研究和开发的最终参考,用于分析这些广泛使用的止痛药.
- 这些发现强调了HPLC和UV/可见光谱光度计在IBU/PAR组合的药品质量控制中的重要性.
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