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Updated: Sep 12, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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VOPP1作为一种在类风湿性关节炎中的新型敏感性基因:从孟德尔随机化和实验验证对其机制的洞察

Weijie Wu1,2, Hao Cai1, Yunyi Nan3

  • 1Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong University Medical School, Nantong, Jiangsu, People's Republic of China.

Journal of inflammation research
|August 7, 2025
PubMed
概括

这项研究确定VOPP1为一种新的类风湿性关节炎 (RA) 易感基因. 通过影响代谢物水平和激活p38 MAPK通路,VOPP1增加了RA风险,为RA提供了新的治疗点.

关键词:
门德尔的随机化这就是VOPP1的原因.表达方式 定量特征 loci loci纤维细胞类同胞细胞类似于纤维细胞.p38 MAPK信号通道的信号通道类风湿性关节炎 类风湿性关节炎在癌症促生存蛋白1中过度表达的囊泡蛋白1

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