复星对绝经后妇女的作用:一个系统的审查和元分析
Weidong Wu1, Tianwei Meng2, Fangfang Jin3
1Key Laboratory of Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Frontiers in pharmacology
|August 7, 2025
概括
复星补充剂可以缓解疼痛,并改善绝经后妇女的骨代谢标志物. 然而,它对认知功能,情绪,代谢健康或其他更年期症状没有显著影响.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 更年期与疼痛增加和骨代谢改变有关.
- 复星是一种葡萄和果中发现的多,已经证明了各种健康益处.
- 复星在治疗更年期症状和相关健康问题的有效性需要进行系统的评估.
研究的目的:
- 系统地评估白醇对绝经后妇女的影响.
- 综合来自随机对照试验 (RCT) 的证据,关于复星对疼痛,认知,情绪,代谢参数和骨标志物的影响.
主要方法:
- 对七个电子数据库进行了系统搜索.
- 使用Stata 12.0.0.进行了元分析.
- 纳入了10项随机对照试验 (RCT),涉及928名参与者.
主要成果:
- Ресвератрол显著降低了疼痛评分 (WMD: -2.841) 和疼痛视觉模拟尺度 (VAS) 评分 (WMD: -7.585).
- 在PPI得分 (WMD: -8.563) 和CTX水平 (WMD: -0.137) 中观察到显著的改善,表明对骨代谢的积极影响.
- 没有发现对认知,情绪,代谢参数,血压,睡眠,更年期症状,生活质量或其他骨标志物 (ALP,OC) 的显著影响.
结论:
- 在绝经后的妇女中,白醇可能对疼痛控制和骨代谢 (CTX) 有好处.
- 目前的证据不支持resveratrol在改善认知功能,情绪,代谢健康或其他更年期症状方面的有效性.
- 需要进一步的大规模试验来证实这些发现,并确定绝经后妇女的最佳白醇剂量和治疗策略.
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