尿液中的重金属负担和癌症风险
Hongqian Ke1, Ning Xie2, Qian Wu3
1Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China.
Frontiers in oncology
|August 7, 2025
概括
尿液中较高的重金属含量,包括和,与美国成年人癌症风险增加有关. 减少接触这些金属对于癌症预防策略至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 在瘤学瘤学.
背景情况:
- 暴露于重金属是一个全球性问题.
- 了解重金属与癌症之间的联系对于公共卫生至关重要.
研究的目的:
- 调查尿路重金属暴露与美国成年人癌症风险之间的关联.
- 量化与特定重金属相关的癌症风险.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (2009-2018) 的数据.
- 使用感应合血质谱法 (ICP-MS) 测量了尿液中的重金属度.
- 使用多变量回归分析和立方平滑图来评估关联.
主要成果:
- 尿液中和含量升高与癌症患病率的增加有显著关联.
- 在这项研究中,与癌症风险没有显著关联.
- 在log2转化尿金属水平和癌症风险之间观察到非线性关联.
结论:
- 增加尿液重金属度与美国成年人患癌症的风险更高有关.
- 建议优先减少重金属暴露,以预防癌症.
- 对特定的金属癌症途径进行进一步研究是有必要的.
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