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口腔微生物组成分预测了三阴性乳腺癌患者对新辅助化疗的反应
Xiaoyan Fu1,2, Ze Huang1,2, Zongyan Li1,2
1Department of General Surgery (Breast Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Frontiers in oncology
|August 7, 2025
概括
口腔微生物组可以预测三阴性乳腺癌 (TNBC) 中的化疗反应. 特定的细菌变化,如增加的乳酸菌和尼塞利亚菌,表明敏感性,为治疗提供非侵入性生物标志物.
科学领域:
- 微生物组研究 微生物组研究
- 在瘤学瘤学.
- 基因组学和蛋白质组学
背景情况:
- 人们越来越认识到口腔微生物组在癌症发展和治疗反应中的作用.
- 它对三阴性乳腺癌 (TNBC) 和化疗敏感性的具体影响尚不清楚.
- 了解这些相互作用对于开发预测生物标志物至关重要.
研究的目的:
- 研究TNBC患者口腔微生物组合和化疗敏感性之间的关联.
- 识别特定的微生物特征,可以预测治疗反应.
- 探索潜在的分子机制,即口腔微生物群对化疗疗效力的影响.
主要方法:
- 对TNBC患者口腔微生物组合的比较分析,这些患者具有不同的化疗敏感性.
- 在化疗前后评估口腔微生物群的变化.
- 开发一种微生物生物标记分类器,以预测化疗敏感性.
主要成果:
- 在化疗敏感和不敏感的TNBC患者之间观察到口腔微生物组合的显著差异.
- 对化疗敏感的患者表现出较高的乳酸菌和尼塞利亚菌,较低的克洛斯特里菌.
- 一个预测分类器的AUC达到77.3%,表明口腔微生物组作为预测生物标志物的潜力.
结论:
- 口腔微生物组的组成根据TNBC的化疗敏感性显著不同.
- 特定的细菌物种 (例如,乳酸菌,尼塞利亚,克洛斯特里) 与治疗反应有关.
- 口腔微生物组显示为预测TNBC中新辅助化疗敏感性的非侵入性,可重复的生物标志物.
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