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便秘是否会影响洗净微生物群移植在治疗自闭症谱系障碍方面的有效性?

Zihao Pan¹, Zheng Gao¹, Junyi Chen¹

¹Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Frontiers in neuroscience

|August 7, 2025

概括

洗微生物种移植 (WMT) 有效地治疗自闭症谱系障碍 (ASD) 症状,并并发性便秘不会影响其长期疗效. 患有自闭症症和便秘的儿童在WMT后表现出改善的肠道健康和微生物多样性.

科学领域:

微生物组研究的研究.
神经发育障碍神经发育障碍
胃肠病学胃肠病学

背景情况:

洗微生物种移植 (WMT) 已证明在改善自闭症谱系障碍 (ASD) 症状方面具有有效性.
便秘对ASD患者WMT有效性的影响尚不清楚.
了解这种相互作用对于优化治疗策略至关重要.

研究的目的:

调查是否便秘的存在会影响WMT在被诊断为ASD的儿童中的疗效.
为了比较ASD患者与没有先前存在的便秘之间的治疗结果.

主要方法:

对接受WMT的103名自闭症患者的回顾性分析.
患者被分为两组:有便秘和没有便秘.
评估了ASD症状,睡眠,胃肠功能,肠道屏障完整性和肠道微生物群组成的变化.

主要成果:

这两组在WMT后的ASD症状和睡眠障碍都有所改善.
便秘在受影响的群体中消失,便形式正常化.
虽然最初的疗效有所不同,但WMT无论便秘状态如何,都表现出可比的长期疗效;便秘组显示微生物多样性增加和Bifidobacteria.

结论:

在便秘和非便秘组中,WMT显著改善了ASD核心症状和睡眠障碍.
自闭症患者的便秘不会阻碍WMT在中期的整体疗效.
肠道微生物群的多样性和组成受到WMT的积极影响,特别是在患有自闭症和便秘的儿童中.

关键词:

自闭症自闭症是什么临床疗效临床疗效便秘便秘便秘便秘肠道屏障的功能是肠道屏障的功能.睡眠障碍睡眠障碍睡眠障碍洗净的微生物群移植移植

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