前列腺素E2和孕激素受体协调调节初级乳毛片,以适当决定化
Chih-Jhen Lee1,2, Yung-Chieh Tsai3,4, Ting-Yu Chen2,5
1Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
概括
初级毛对于决定化至关重要,这是使胚胎植入成为可能的过程. 这项研究表明,毛长度增加支持决定化,而缺陷与流产相关,揭示了涉及前列腺素E2 (PGE2) 和孕激素受体 (PGR) 的关键途径.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 脱二化对于成功怀孕至关重要,涉及子宫内膜层细胞分化.
- 主要的乳毛,细胞天线,涉及到各种细胞分化过程.
- 主性乳毛在人类决定性和早期妊娠并发症中的作用尚不清楚.
研究的目的:
- 研究在体外和体内生物决定过程中初级毛的作用和调节.
- 探索初级毛缺陷和反复流产之间的关联.
- 阐明将初级乳毛动态与决定化联系起来的分子机制.
主要方法:
- 在人体子宫内膜层细胞中对初级毛囊的时间过程分析,这些细胞正在进行体外结核化.
- 使用小鼠模型进行体内研究,以评估交后的状变化.
- 来自反复流产的女性子宫内膜组织的分析.
- 实验性操纵初级眼功能 (消耗/抑制) 和分子通路分析 (PGE2-PKA-CREB1-PGR).
主要成果:
- 纤毛细胞的比例和纤毛细胞的长度都在体外决定化过程中显著增加.
- 在小鼠中,阴毛长度在合后逐渐增加,而在女性中观察到有缺陷的初级阴毛,这些女性经常流产.
- 主要毛是决定化所需的,它们的枯竭会损害这个过程.
- PGE2-PKA-CREB1通路调节状细胞的生长和孕激素受体 (PGR) 表达,而PGR进一步增强了状细胞的长度.
结论:
- 主要乳毛长度与决定化的程度直接相关.
- 子宫内膜中缺陷的初级乳毛可能会导致经常性流产.
- PGE2和PGR信号顺序调节状动力学,突出了成功植入和胎盘形成所必不可少的新机制.
相关概念视频
01:22Hormonal Regulation of the Menstrual Cycle
700
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
700
01:27Feedback Regulation of Calcium Concentration
3.5K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.5K
01:27Ovarian Cycle
1.9K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.9K
01:30Hormonal Control of the Ovarian Cycle
2.8K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
2.8K
01:22Microtubules in Signaling
1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
01:19Secretory Phase
1.3K
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
1.3K