相关实验视频
Updated: Sep 12, 2025

10:46
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
18.9K
单次口服德罗纳比诺尔增加了眼球血流在患有玻璃眼瘤的患者
Theresa Lindner1, Viktoria Pai1, Patrick Janku1
1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Acta ophthalmologica
|August 7, 2025
概括
视神经头部血流 (ONHBF) 在患者中显著改善. 这表明dronabinol作为一种额外的治疗方法来解决绿眼的血管问题.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 玻璃眼是全球不可逆转的失明的主要原因.
- 眼内血压升高 (IOP) 是主要的驱动因素,但有些患者尽管接受治疗,但仍有进展,可能是由于眼部血流受损.
- 这项研究研究了dronabinol对初级开角玻璃眼 (POAG) 的眼球血流的影响.
研究的目的:
- 为了评估dronabinol的作用,一个合成的四大麻衍生物,在初级开角玻璃眼 (POAG) 患者的眼睛血液流动.
- 评估德罗纳能否改善视神经头部 (ONH) 和视网膜血管系统的血液流动.
主要方法:
- 一项随机,双面膜,安慰剂控制,交叉研究,涉及23名POAG患者.
- 参与者在单独的研究日接受了5mg或10mg的德罗纳比诺尔或安慰剂.
- 视神经头部血流量 (ONHBF) 使用激光斑点流图进行测量,其次要结果包括通过光相干断层扫描血管学,IOP和血压测量血管密度.
主要成果:
- 与安慰剂相比,10mg的德罗纳宾醇在服用后4小时内显著增加了ONHBF (MA,MV,MT) (p<0.05).
- 德罗纳宾醇没有显著影响眼内压力 (IOP) 或平均动脉压力.
- 与5mg相比,10mg的德罗纳宾醇观察到表面血管血管密度的显著增加.
结论:
- 系统性德罗纳醇可增强青光眼患者的ONHBF,表明其作为辅助治疗的潜力.
- 德罗纳宾醇可能有助于解决青光眼的血管功能障碍.
- 需要进行进一步的纵向研究,以确定其对青光眼进展和视野保护的长期影响.
相关概念视频
Open Angle Glaucoma: Treatment
570
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
570
Glaucoma: Overview
762
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
762
Angle Closure Glaucoma: Treatment
684
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
684
Drug Delivery: Miscellaneous Routes
468
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468
Additional Routes of Drug Administration
3.1K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
3.1K

