益生菌Parabacteroides johnsonii通过促进BCAA转化为BSCFA改善代谢障碍
Yimeng Chen1,2, Shujun Jiang3, Haolu Wang2
1Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, China Pharmaceutical University, 639 Longmian road, Nanjing, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 7, 2025
概括
肠道细菌Parabacteroides johnsonii显示了对代谢障碍的治疗潜力. 这项研究发现,它改善了肠道健康,减少了炎症,提供了新的治疗途径.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 我们的肠道微生物组.
背景情况:
- 帕拉巴克特罗伊德 (Parabacteroides spp.) 的一种. 在代谢障碍方面显示出治疗潜力.
- 在代谢障碍中Parabacteroides johnsonii的特定作用仍然未被描述.
研究的目的:
- 调查Parabacteroides johnsonii在代谢障碍中的作用.
- 阐明P. johnsonii发挥其作用的机制.
主要方法:
- 在肥胖患者中,P. johnsonii丰富度与代谢参数的相关性分析.
- 在高脂肪饮食诱导的肥胖小鼠中,口服P. johnsonii.
- 分析肠道屏障完整性,全身炎症和代谢物概况.
- 调查异黄酸盐和稳糖干预措施的影响.
主要成果:
- 在肥胖患者中,P. johnsonii的丰度与血糖和脂质水平有负相关性.
- 在小鼠中,口服P. johnsonii改善了代谢功能障碍,减少了漏肠和全身炎症.
- P. johnsonii增强了分支链氨基酸转化为分支链短链脂肪酸 (BSCFAs),特别是酸转化为异黄酸.
- 异酸盐模仿P. johnsonii的作用,通过抑制HDAC3增加H3K14乙化和FGF1B转录,改善肠道屏障.
- 葡萄糖促进了P. johnsonii的生长,并表现出抗肥胖作用.
结论:
- P. johnsonii在代谢障碍方面显示出显著的治疗潜力.
- 异芽酸盐调解P. johnsonii对肠道屏障完整性和新陈代谢的有益影响.
- 葡萄糖可能是一种增强P. johnsonii代谢健康的益生菌.
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